EasyMount® Ussing Chambers Featured in Cystic Fibrosis Research News
We’re excited to share that our EasyMount® Ussing Chamber Systems were recently highlighted in a press release on OpenPR. The article showcases how our technology is helping advance research into CFTR modulators for cystic fibrosis (CF), one of the most impactful areas of epithelial transport science today.
Article Link: EasyMount® Ussing Chambers from Physiologic Instruments Advance CFTR and Cystic Fibrosis Research
Why Ussing Chambers Matter in Cystic Fibrosis Research
Cystic fibrosis is caused by mutations in the CFTR gene, which regulates chloride and bicarbonate transport across epithelial tissues. These defects lead to thickened mucus in the lungs and other organs.
To evaluate the effectiveness of new therapies such as ivacaftor, lumacaftor, and the triple combination elexacaftor/tezacaftor/ivacaftor, researchers need reliable tools to measure whether ion transport is restored.
That’s where the EasyMount Ussing Chamber comes in. By enabling precise short-circuit current (Isc) and transepithelial resistance (TER/TEER) measurements, EasyMount provides researchers with reproducible, high-fidelity data to assess drug responses in both native tissue and cultured cell monolayers.
Trusted in Translational Science
Peer-reviewed studies across journals such as the European Respiratory Journal and Scientific Reports cite Physiologic Instruments Ussing chambers in their methods. Researchers worldwide rely on these systems for:
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CFTR function testing in patient-derived nasal and airway epithelial cultures
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Epithelial barrier integrity research in lung and gastrointestinal models
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Pharmacological screening for new ion channel modulators
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Educational and teaching labs introducing students to electrophysiology techniques
About Physiologic Instruments
Physiologic Instruments designs and manufactures Ussing chambers, voltage-current clamps, and data acquisition systems for epithelial transport and barrier function research. From academic teaching labs to clinical and pharmaceutical research programs, our products are trusted globally for their reliability and precision.