6-Channel Voltage Current Clamp with OptiGain
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Product Details
The 6-Channel Voltage Current Clamp with OptiGain is a multi-channel voltage/current clamp designed to be a flexible tool for studying ion transport mechanisms by in vitro epithelial tissues. It provides the capability to control either the voltage or the current across epithelial tissues, thereby enabling one to measure electrophysiological responses to drugs, hormones, and/or ion substitutions as well as to compare measurements of ionic flux with the short-circuit current. The voltage/current clamp is suitable for use with both "leaky" and "tight" epithelia, tissue samples or cell culture, and works for a very wide range of tissue area. The optiGain feature enables the user to optimize the instrument for the characteristics of the tissue under study by setting the current gain and fluid resistance compensation range from a pair of switches located on the front panel.
The 6-Channel Voltage Current Clamp offers these features:
- A built-in pulse generator for monitoring of the tissue conductance/resistance (TEER).
- Up to six (depending on the model) independently controlled voltage/current clamp channels.
- Digital readout of the transepithelial voltage or current.
- Compensation for electrode asymmetry potentials over user selectable ranges of ±10 mV or ±100 mV.
- Automatic compensation for voltage errors due to the resistance of the fluid in series with the epithelium - fluid resistance compensation (FRC).
- The ability to clamp either the voltage or current to any dc level in the range ±100 mV or uA.
- A Master Control switch that permits "one-touch" control of all clamp units.
Recorder outputs for continuous monitoring of the transepithelial voltage and current. - A pulse generator output providing +, - or bipolar pulses.
- An external command signal input to allow an arbitrary waveform to be clamped.
A remote control interface jack to allow the Multi-Channel Voltage Current Clamp to be controlled directly by computer using the ACQUIRE & ANALYZE© data acquisition and analysis system or other such remote interface.
optiGain - switch selectable current gain and fluid resistance compensation range.
6-Channel Voltage Current Clamp options:
- VCC MC6-6S Voltage Current Clamp includes: (1) VCC MC6 voltage/current clamp, (6) DM-MC6 input modules with integral dummy membrane, (6) MC-601 Voltage/Current Clamp channels, (1) optiGain for switching gain and fluid resistance ranges. Can be expanded up to (6) clamp channels using MC-601 plug in modules.
- VCC MC6-4S Voltage Current Clamp includes: (1) VCC MC 6 voltage/ current clamp, (4) MC-601 clamp modules, (4) DM-MC6 input modules with integral dummy membrane, and (1) optiGain for switching gain and fluid resistance ranges. Can be expanded to (6) clamp channels using plug in modules. Can be expanded up to (6) clamp channels using MC_601 plug in modules.
- VCC MC6-2S Voltage Current Clamp includes:(1) VCC MC6 voltage/current clamp, 2) DM-MC6 input modules with integral dummy membrane, (2) MC-601, (1) optiGain for switching gain and fluid resistance ranges. Can be expanded to (6) clamp channels using plug in modules. Can be expanded up to (6) clamp channels using MC-601 plug in modules.