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The P2303A Ussing Chamber Slider from Physiologic Instruments is precisely designed to support high-precision physiological studies on small tissue specimens, including mouse intestine and bladder. With a 2.7 x ~4 mm aperture and an optimized 0.10 cm² exposure area, this specialized slider offers a refined platform that enhances experimental accuracy and reproducibility for delicate samples. Its design ensures that tissues receive uniform exposure, contributing to more reliable data in studies focused on transport and barrier function.

This slider is compatible with the EasyMount Chamber Model P2300 and incorporates six mounting pins for secure sample stabilization without compromising tissue integrity. The P2303A’s robust yet sensitive configuration allows researchers to handle and maintain small, fragile tissues with confidence, reducing mechanical stress and improving the quality of results. Tailored to the needs of specialized physiological research, the P2303A Ussing Chamber Slider exemplifies advanced engineering for laboratory environments demanding precision and dependability.

The P2307 EasyMount Ussing Chamber Slider is a precise and efficient accessory for the P2300 Ussing Chamber System, ideal for human biopsy studies, including duodenal, colonic, and rectal samples. Its 2 mm diameter circular aperture, covering a focused area of 0.031 cm², allows for detailed measurement of ion transport and barrier function within small, targeted tissue sections.

The EasyMount design facilitates quick, secure mounting without pins, preserving sample integrity. In combination with the P2300 system, the P2307 Slider ensures stable and reproducible conditions, making it a valuable tool for high-resolution epithelial research on biopsy specimens.

The Corning Transwell Snapwell has become a mainstay for growing epithelial cells. Its large area (1.12 cm2) and shallow depth are ideal for transport and electrophysiological research in the EasyMount Ussing chamber. The P2302 EasyMount Slider is designed to securely hold these inserts without stress on the membrane and to position the membrane perfectly between the two halves of the P2300 Ussing chamber.

The mounting procedures for placing the Snapwell into the P2302 slider and then into the chamber are both easy and fast. The Snapwell is removed from the culture dish, separated from its holder, drained of media, and placed with its basal side against the red O-ring in the P2302 slider. Wipe the end and sides of the slider to remove any saline and “slide” the Snapwell+P2302 in the slot between the two chamber halves until it reaches the hard stop. Turn the thumbscrew on the chamber to gently squeeze the chamber halves together. Only light pressure between the chamber halves and the slider is required to make a watertight seal. Excessive pressure can distort the culture membrane and alter the electrical parameters. The procedure for mounting the tissue takes less than 30 seconds to accomplish. This system is ideal for transport and electrophysiological measurements. The P2302 enables effortless transfer of confluent cell layers directly into EasyMount Ussing Chambers, providing researchers with a streamlined, effective solution for high-quality results.

The P2314 EasyMount Ussing Chamber Slider is a precision-engineered tissue holder for the EasyMount P2300 Ussing Chamber System, designed with a 11.28 mm circular aperture (1.00 cm²) and equipped with mounting pins. This configuration stabilizes tissues like rabbit intestine and bladder, providing a larger exposed area ideal for studies requiring comprehensive sampling. The mounting pins ensure sample stability, preventing movement and ensuring consistent, reproducible measurements essential for accurate physiological assessments of epithelial transport and barrier integrity.

The P2309 EasyMount Ussing Chamber Slider is a 4.0 mm diameter tissue holder for the P2300 Ussing Chamber System, designed with a 0.126 cm² round aperture and equipped with mounting pins to secure tissues like mouse intestine and bladder. Its pin-supported design stabilizes samples, reducing movement and ensuring integrity during experiments, which is especially beneficial for thicker or flexible tissues.

This configuration provides a controlled environment for precise studies of ion transport, permeability, and barrier function, making the P2309 a valuable tool for physiological research on epithelial tissues.

The P2305S Ussing Chamber Slider is purpose-built for physiological studies involving larger, elongated tissue specimens, such as those from rat, guinea pig, or rabbit intestine. With a 4.5 x 11.2 mm aperture and a 0.5 cm² exposure area, this slider provides an expanded surface optimized for examining transport and barrier functions in larger tissue samples, with a supporting silver electrode built into the slider.

Designed for seamless compatibility with the EasyMount Chamber Model P2300, the P2305S slider offers a stable and precise platform for securely positioning extended tissue sections. The elongated aperture ensures consistent exposure across the sample, enhancing data reliability and facilitating controlled studies. The P2305S Ussing Chamber Slider is an ideal choice for researchers requiring a larger exposure area for rigorous experiments on substantial tissue specimens.