P2404S EasyMount Slider
The P2404 EasyMount Low Volume Slider is engineered for use with the Low Volume EasyMount Chamber Model P2400, designed to support small tissue specimens, such as mouse intestine, in transport and permeability studies. Featuring an aperture of 2.8 x 9.2 mm (0.25 cm² area) and incorporating eight stainless steel mounting pins, the P2404 slider provides secure, stable positioning for delicate tissues, preserving specimen integrity and alignment. Its low-volume design allows experiments with reduced solution requirements, enhancing precision in physiological measurements. This slider is an essential tool for researchers seeking reliable and reproducible data on barrier function and transport properties in Ussing chamber systems, particularly within small animal models.
⦿ To be used with P2400 EasyMount Low-Volume Chambers- Regular price
- $318.00
- Regular price
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- Sale price
- $318.00
- Unit price
- per
EasyMount Slider Details
P2404S EasyMount Low Volume Slider for Mouse Intestine
APETURE SIZE: 2.8x9.2MM | Area = 0.25 cm2 | with Silver Electrodes
The P2404S EasyMount Low Volume Slider is a specialized tool designed for use with the Low Volume EasyMount Chamber Model P2400, particularly suited for studies involving small tissue specimens such as mouse intestine. With an aperture area of 0.25 cm² (2.8 x 9.2 mm), the P2404S slider features eight stainless steel pins that securely mount delicate tissue samples, ensuring stable orientation and minimal stress during experimentation. This low-volume configuration allows researchers to conduct transport, permeability, and barrier function studies with minimal solution requirements, preserving tissue integrity while enabling precise physiological measurements.
Silver electrodes for transmural stimulation work with the P2404S EasyMount Slider in the P2400 Low Volume Ussing Chamber system by delivering a controlled electrical current across the mounted tissue, facilitating studies on tissue responsiveness and ion transport dynamics. The P2404S slider is designed to hold small tissue samples securely within the Ussing Chamber, ensuring proper orientation and stability during stimulation. When silver electrodes are introduced into each chamber compartment, they are positioned on either side of the tissue specimen, allowing the tissue to act as a barrier between the electrodes.
In this setup, the silver electrodes function by generating an electrical field across the tissue layer, which is especially useful for studies that require stimulation of excitable tissues, such as smooth muscle or epithelial layers in organs like the intestine. When a current is applied, the electrical field created across the tissue can stimulate ion channels, transport proteins, and other electrically responsive components within the tissue. This transmural stimulation helps researchers observe the effects of an electrical gradient on ion transport, permeability, and cellular responses. The precise placement and low-volume design of the P2404S slider, combined with the effective conductivity of silver electrodes, provide a controlled and reproducible environment for analyzing tissue function and responses under electrical stimulation within the P2400 EasyMount Ussing Chamber system.